Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy
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چکیده
منابع مشابه
Non-invasive biomarkers FibroTest-ActiTest for replacing invasive liver biopsy: the need for change and action.
J Gastrointestin Liver Dis June 2007 Vol.16 No 2, 173-174 Address for correspondence: 1 Bedossa et al. found the best diagnostic value for discriminating between F0-F1 and F2-F4 METAVIR that can be obtained for the liver biopsy versus the entire liver is 0.90 AUROC for a 20mm nonfragmented liver biopsy. 2 Regev et al. suggested that an adequate non fragmented liver biopsy sample contain more th...
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Introduction: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease ranging from simple steatosis to inflammatory steatohepatitis (NASH) with increasing levels of fibrosis and ultimately cirrhosis. It has been considered the most common liver disease and the most frequent cause of elevated aminotransferases and cryptogenic cirrhosis. Aims and Objectives: To evaluate the ro...
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With great advancements in the therapeutic modalities used for the treatment of chronic liver diseases, the accurate assessment of liver fibrosis is a vital need for successful individualized management of disease activity in patients. The lack of accurate, reproducible and easily applied methods for fibrosis assessment has been the major limitation in both the clinical management and for resea...
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Chronic liver diseases (CLDs), including chronic hepatitis C and B, alcoholic and non-alcoholic fatty liver diseases, represent a major cause of morbidity and mortality worldwide. The progressive accumulation of fi brosis in the liver characterizes the natural history of CLDs and represents the hallmark of the evolution towards hepatic cirrhosis and its end-stage complications (1) . Staging of ...
متن کاملSimple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease
BACKGROUND AND AIMS Non-alcoholic fatty liver disease (NAFLD) is a common, morbid disease with profound implications for the overall health of the patient. We set out to determine the clinical predictors of advanced histology in the referral population. METHODS We performed a retrospective review of all biopsy-proven NAFLD patients, including 358 unique patients first seen between 1996 and 20...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2006
ISSN: 1007-9327
DOI: 10.3748/wjg.v12.i23.3682